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CS-W001157 4
Total: USD 88.00

Famotidine impurity 6

  • CAS No. 76824-16-3

  • Cat. No. CS-0378860
  • Molecule weight259.35
  • Purity≥98%
  • MDL No.MFCD27966021

*For research and further manufacturing use only, not for direct human use.

Famotidine impurity 6|CS-0378860

Structure of 76824-16-3

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General Information

  • CAS No. 76824-16-3
  • Cat. No. CS-0378860
  • Purity ≥98%
  • MDL No. MFCD27966021
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃N₅OS₂
  • Molecular Weight 259.35
  • Synonym(s) None
  • SMILES O=C(N)CCSCC=1N=C(SC1)NC(=N)N

Description

A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 M, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).

Synthesis

  • Route1
    • Famotidine impurity 11|CS-0815545
      76823-94-4
    • ~65%
    • Famotidine impurity 6|CS-0378860
      76824-16-3

    References

    • Yanagisawa; Hirata; Ishii Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
  • Route2
    • Famotidine Impurity 33|CS-1004795
      76823-89-7
    • ~%
    • Famotidine impurity 6|CS-0378860
      76824-16-3

    References

    • Yanagisawa; Hirata; Ishii Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
  • Route3
    • Famotidine impurity 16|CS-W012790
      76823-93-3
    • ~%
    • Famotidine impurity 6|CS-0378860
      76824-16-3

    References

    • Yanagisawa; Hirata; Ishii Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   117.88
  • LogP   0.55707
  • H_Acceptors   5
  • H_Donors   4
  • Rotatable_Bonds   6

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