2-Chloro-5-methylpyridin-4-amine

CAS No. 79055-62-2
Cat. No. CS-W021662
Purity≥97%
MDL No.None

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2-Chloro-5-methylpyridin-4-amine|CS-W021662

Structure of 79055-62-2

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Description

2-Chloro-5-methylpyridin-4-amine features a pyridine core bearing a chloro group at C2 and a methylamino substituent at C4, delivering a potent electrophilic handle. This electron-deficient heterocycle integrates readily into cross-coupling reactions, enabling efficient access to advanced pharmaceutical intermediates and functionalized materials under standard conditions.

Application

2-Chloro-5-methylpyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. The chloro group facilitates palladium-catalyzed cross-coupling reactions, while the pyridin-4-amine functionality supports further derivatization via nucleophilic substitution or metal-mediated transformations. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for synthesizing targeted heterocyclic compounds and API intermediates.

General Information

CAS No. 79055-62-2
Cat. No. CS-W021662
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂
Molecular Weight 142.59
Synonym(s) 4-Pyridinamine, 2-chloro-5-methyl-
SMILES NC1=CC(Cl)=NC=C1C

Computational Chemistry Data

TPSA 38.91
LogP 1.62562
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-methylpyridin-4-amine

CAS No. 79055-62-2

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