Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-(Bromomethyl)-4-fluoro-1-nitrobenzene

  • CAS No. 82420-35-7

  • Cat. No. CS-0036364
  • Purity≥95%
  • MDL No.MFCD09736331

*For research and further manufacturing use only, not for direct human use.

2-(Bromomethyl)-4-fluoro-1-nitrobenzene|CS-0036364

Structure of 82420-35-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 82420-35-7
  • Cat. No. CS-0036364
  • Purity ≥95%
  • MDL No. MFCD09736331
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrFNO₂
  • Molecular Weight 234.02
  • Synonym(s) 5-Fluoro-2-nitro benzylbromide
  • SMILES C1=C(C=C(CBr)C(=C1)[N+](=O)[O-])F

Description

2-(Bromomethyl)-4-fluoro-1-nitrobenzene features a bromomethyl group flanked by electron-withdrawing nitro and fluoro substituents, enabling selective functionalization in late-stage diversification. This electrophilic handle integrates readily into cross-coupling and nucleophilic substitution cascades under mild conditions, delivering complex aryl architectures with high chemoselectivity.

Application

2-(Bromomethyl)-4-fluoro-1-nitrobenzene serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient construction of complex heterocyclic scaffolds and pharmaceutical intermediates. The bromomethyl group facilitates nucleophilic substitution and palladium-catalyzed coupling reactions, while the fluorine and nitro groups provide orthogonal reactivity and enhanced electronic modulation. Its bench-stable nature and compatibility with standard purification methods make it well-suited for multi-step synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Pfizer Inc Patent: US2010/324043 A1, 2010 ; Location in patent: Page/Page column 26-27 ;
  • Route2

    References

    • Wyeth Holdings Corporation Patent: EP1147095 B1, 2004 ; Location in patent: Page 91 ;
  • Route3
    • null|null
      558-13-4
    • In-stock
      (5-Fluoro-2-nitrophenyl)methanol|CS-W003267
      287121-32-8
    • ~91%
    • In-stock
      2-(Bromomethyl)-4-fluoro-1-nitrobenzene|CS-0036364
      82420-35-7

    References

    • American Cyanamid Company Patent: US6544984 B1, 2003 ; US 6544984 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   43.14
  • LogP   2.6288
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-(Bromomethyl)-4-fluoro-1-nitrobenzene sigma2-(Bromomethyl)-4-fluoro-1-nitrobenzene manufacturer2-(Bromomethyl)-4-fluoro-1-nitrobenzene price2-(Bromomethyl)-4-fluoro-1-nitrobenzene structure2-(Bromomethyl)-4-fluoro-1-nitrobenzene SDSbuy 2-(Bromomethyl)-4-fluoro-1-nitrobenzene2-(Bromomethyl)-4-fluoro-1-nitrobenzene supplier2-(Bromomethyl)-4-fluoro-1-nitrobenzene uses2-(Bromomethyl)-4-fluoro-1-nitrobenzene molecular weightprice of 2-(Bromomethyl)-4-fluoro-1-nitrobenzene2-(Bromomethyl)-4-fluoro-1-nitrobenzene chemical name formula of 2-(Bromomethyl)-4-fluoro-1-nitrobenzene
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label