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Structure of 83249-08-5
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This bicyclic scaffold features a rigid, strained cage structure with a pendant hydroxyl and carboxylic acid group. The 3-hydroxy functionality enables direct derivatization or hydrogen bonding interactions, while the carboxylic acid provides a handle for amide coupling or salt formation. Designed for bioisosteric replacement in medicinal chemistry, this compound offers enhanced metabolic stability and controlled conformational flexibility compared to linear analogs.
3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid serves as a rigid, sterically constrained scaffold for medicinal chemistry and synthetic applications. Its bicyclic core imparts high metabolic stability and conformational restriction, while the carboxylic acid and hydroxyl groups enable diverse functionalization via standard coupling and derivatization reactions. The compound exhibits excellent bench stability and compatibility with common protecting group strategies, facilitating integration into complex molecule synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: