Thalidomide 4-fluoride

CAS No. 835616-60-9
Cat. No. CS-B1597
Purity≥95%
MDL No.MFCD11840666

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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Description

Thalidomide 4-fluoride features a fluorinated analog of thalidomide, where the para-fluoro substitution enhances metabolic stability and modulates target engagement. This derivative retains the core immunomodulatory scaffold while improving pharmacokinetic properties for research applications in oncology and inflammatory disease modeling.

Application

Thalidomide 4-fluoride serves as a fluorinated analog of thalidomide, enabling targeted exploration of structure-activity relationships within the glutarimide class. Its enhanced metabolic stability and modulated electronic properties facilitate studies in protein degradation pathways, particularly in the context of cereblon-mediated E3 ligase recruitment. The compound functions as a valuable tool for probing the influence of fluorine substitution on pharmacokinetics and target engagement in oncology and immunomodulatory research.

General Information

CAS No. 835616-60-9
Cat. No. CS-B1597
Purity ≥95%
MDL No. MFCD11840666
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₉FN₂O₄
Molecular Weight 276.22
Synonym(s) Cereblon ligand 4; E3 ligase Ligand 4
SMILES O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O

Computational Chemistry Data

TPSA 83.55
LogP 0.2102
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science Linker PROTAC Linkers

Life Science PROTAC Ligands for E3 Ligase

General Reagents Organic General Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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Thalidomide 4-fluoride

CAS No. 835616-60-9

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