6-Bromo-2-methoxypyridin-3-amine

CAS No. 89466-18-2
Cat. No. CS-W006184
Purity≥96%
MDL No.MFCD06738312

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Bromo-2-methoxypyridin-3-amine|CS-W006184

Structure of 89466-18-2

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Description

6-Bromo-2-methoxypyridin-3-amine features a pyridine core bearing bromine at the 6-position and a methoxy group at the 2-position, creating a uniquely activated heterocyclic scaffold. This configuration enables direct coupling reactions in late-stage functionalization. The amine functionality at the 3-position serves as a key handle for C–N bond formation. The molecule exhibits enhanced solubility in polar organic solvents and stability under standard bench conditions, facilitating use in synthetic workflows requiring reliable reactivity and ease of handling.

Application

6-Bromo-2-methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromine handle and compatible methoxy and amino substituents. The molecule exhibits excellent bench stability and facilitates efficient functionalization in late-stage diversification of heterocyclic scaffolds. Its orthogonal reactivity profile supports selective transformations in complex synthesis workflows.

General Information

CAS No. 89466-18-2
Cat. No. CS-W006184
Purity ≥96%
MDL No. MFCD06738312
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇BrN₂O
Molecular Weight 203.04
Synonym(s) 6-Bromo-2-methoxypyridin-3-ylamine
SMILES COC1=NC(Br)=CC=C1N

Computational Chemistry Data

TPSA 48.14
LogP 1.4349
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Bromo-2-methoxypyridin-3-amine

CAS No. 89466-18-2

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