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Structure of 898044-48-9
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4-Chloropyrimidine-2-carbonitrile serves as a pivotal heterocyclic scaffold in medicinal chemistry, featuring a chlorine atom at C4 and a nitrile group at C2. This combination enables direct functionalization via nucleophilic substitution or metal-catalyzed coupling reactions. The electron-deficient pyrimidine ring facilitates efficient derivatization under mild conditions, making it ideal for constructing bioactive molecules and advanced intermediates in drug discovery pipelines.
4-Chloropyrimidine-2-carbonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its dual electrophilic sites—chlorine at C4 and nitrile at C2—facilitate sequential functionalization via nucleophilic substitution and condensation reactions. Bench-stable and readily purified by recrystallization, it supports scalable synthesis of targeted heterocycles and API intermediates with high functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: