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CS-W001157 4
Total: USD 88.00

3-Formyl-4-methoxybenzoic acid

  • CAS No. 91420-99-4

  • Cat. No. CS-0143798
  • Molecule weight180.16
  • Purity≥98%
  • MDL No.MFCD12405165

*For research and further manufacturing use only, not for direct human use.

3-Formyl-4-methoxybenzoic acid|CS-0143798

Structure of 91420-99-4

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General Information

  • CAS No. 91420-99-4
  • Cat. No. CS-0143798
  • Purity ≥98%
  • MDL No. MFCD12405165
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈O₄
  • Molecular Weight 180.16
  • Synonym(s) None
  • SMILES O=C(O)C1=CC=C(OC)C(C=O)=C1

Description

3-Formyl-4-methoxybenzoic acid features a formyl group at the meta position relative to the carboxylic acid, paired with a para-methoxy substituent. This electron-rich aromatic scaffold enables direct coupling in cross-coupling reactions and serves as a key building block for bioactive heterocycles. The molecule exhibits enhanced solubility in polar organic solvents and maintains stability under standard bench conditions.

Application

3-Formyl-4-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at both the aldehyde and carboxylic acid termini. Its orthogonal reactivity facilitates efficient coupling, amidation, or reductive amination workflows, while the methoxy group enhances solubility and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses of heterocyclic scaffolds and bioactive molecule intermediates.

Synthesis

  • Route1
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    • ~%
    • In-stock
      3-Formyl-4-methoxybenzoic acid|CS-0143798
      91420-99-4

    References

    • Chattaway; Calvet Journal of the Chemical Society, 1928 , p. 2917
  • Route2
    • p-Anisic acid, ≥99%|CS-1268349
      100-09-4
    • ~%
    • In-stock
      3-Formyl-4-methoxybenzoic acid|CS-0143798
      91420-99-4

    References

    • Chattaway; Calvet Journal of the Chemical Society, 1928 , p. 2917
  • Route3
    • null|null
      7664-93-9
    • null|null
      99184-44-8
    • ~%
    • In-stock
      3-Formyl-4-methoxybenzoic acid|CS-0143798
      91420-99-4

    References

    • Chattaway; Calvet Journal of the Chemical Society, 1928 , p. 2917

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   63.6
  • LogP   1.2059
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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