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CS-W001157 4
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Cabozantinib impurity 1

  • CAS No. 918642-61-2

  • Cat. No. CS-0166295
  • Molecule weight223.20
  • Purity≥98%
  • MDL No.MFCD16676129

*For research and further manufacturing use only, not for direct human use.

Cabozantinib impurity 1|CS-0166295

Structure of 918642-61-2

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General Information

  • CAS No. 918642-61-2
  • Cat. No. CS-0166295
  • Purity ≥98%
  • MDL No. MFCD16676129
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀FNO₃
  • Molecular Weight 223.20
  • Synonym(s) None
  • SMILES O=C(C1(C(NC2=CC=CC=C2F)=O)CC1)O

Synthesis

  • Route1
    • null|null
      348-54-9
    • ~52%
    • In-stock
      Cabozantinib impurity 1|CS-0166295
      918642-61-2

    References

    • Eisai RandD Management Co., Ltd. Patent: EP1889836 A1, 2008 ; Location in patent: Page/Page column 52 ;
  • Route2
    • null|null
      40258-99-9
    • null|null
      348-54-9
    • ~%
    • In-stock
      Cabozantinib impurity 1|CS-0166295
      918642-61-2

    References

    • Saavedra, Oscar; Claridge, Stephen; Zhan, Lijie; Raeppel, Franck; Granger, Marie-Claude; Raeppel, Stephane; Mannion, Michael; Gaudette, Frederic; Zhou, Nancy; Isakovic, Ljubomir; Bernstein, Naomy; Deziel, Robert; Nguyen, Hannah; Beaulieu, Normand; Beaulieu, Carole; Dupont, Isabelle; Wang, James; Macleod, A. Robert; Besterman, Jeffrey M.; Vaisburg, Arkadii Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6836 - 6839

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   1.629
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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