Sitagliptin impurity 5

CAS No. 936630-57-8
Cat. No. CS-0012818
Purity≥95%
MDL No.MFCD07363507

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 936630-57-8

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Description

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid is a chiral building block featuring a sterically hindered amino acid scaffold with a trifluorophenyl group that imparts enhanced metabolic stability. This configuration enables efficient incorporation into peptide-based pharmaceuticals, particularly where electron-deficient aromatic moieties are required for target engagement. The molecule exhibits excellent bench-stability and solubility under standard conditions.

Application

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid serves as a valuable chiral building block for the synthesis of bioactive molecules, particularly in medicinal chemistry and peptide-based drug discovery. Its well-defined stereochemistry and compatibility with standard amino acid transformations enable reliable incorporation into complex scaffolds. The trifluorophenyl group enhances metabolic stability and modulates lipophilicity, while the pendant amine and carboxylic acid functionalities allow for diverse conjugation strategies. Bench-stable and amenable to purification via crystallization or chromatography, it functions effectively in multi-step syntheses requiring functional group tolerance and predictable reactivity.

General Information

CAS No. 936630-57-8
Cat. No. CS-0012818
Purity ≥95%
MDL No. MFCD07363507
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₀F₃NO₂
Molecular Weight 233.19
Synonym(s) None
SMILES FC1=CC(C[C@@H](N)CC(O)=O)=C(F)C=C1F

Computational Chemistry Data

TPSA 63.32
LogP 1.4484
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 4

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

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Sitagliptin impurity 5

CAS No. 936630-57-8

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