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CS-W001157 4
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2-Fluoro-1H-indole

  • CAS No. 944347-13-1

  • Cat. No. CS-0131024
  • Molecule weight135.14
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-1H-indole|CS-0131024

Structure of 944347-13-1

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General Information

  • CAS No. 944347-13-1
  • Cat. No. CS-0131024
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆FN
  • Molecular Weight 135.14
  • Synonym(s) None
  • SMILES FC(N1)=CC2=C1C=CC=C2

Description

2-Fluoro-1H-indole features a fluorine atom at the 2-position of the indole scaffold, imparting enhanced electron-withdrawing character and metabolic stability. This substitution pattern enables direct incorporation into bioactive molecules, particularly in pharmaceuticals and agrochemicals where modulated lipophilicity and electronic properties are critical. The compound exhibits robust bench stability and compatibility with standard synthetic transformations.

Application

2-Fluoro-1H-indole serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position via electrophilic substitution or transition-metal-catalyzed coupling. Its fluorinated indole core imparts enhanced metabolic stability and modulated electronic properties, making it valuable for constructing bioactive heterocycles. The compound exhibits good bench stability and compatibility with common reaction conditions, facilitating efficient incorporation into diverse scaffolds through standard synthetic protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   2.307
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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