5,6-Difluoroindole

Name: 5,6-Difluoroindole
Brand: ChemScene
Availability: InStock
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CAS No. 169674-01-5
Cat. No. CS-W009079
Purity≥98%
MDL No.MFCD01075212

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Structure of 169674-01-5

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Description

5,6-Difluoroindole features two fluorine atoms at the 5- and 6-positions of the indole core, imparting enhanced electron deficiency and improved metabolic stability. This substitution pattern increases reactivity in cross-coupling processes while maintaining bench-stable handling properties. The molecule integrates readily into complex heterocyclic architectures used in medicinal chemistry and materials science.

Application

5,6-Difluoroindole serves as a valuable building block in medicinal chemistry, enabling direct incorporation of fluorinated heterocycles into bioactive molecules. The difluoro substitution enhances metabolic stability and modulates electronic properties, while maintaining compatibility with standard coupling reactions. Its bench-stable nature and predictable reactivity facilitate efficient synthesis of complex scaffolds in drug discovery workflows.

General Information

CAS No. 169674-01-5
Cat. No. CS-W009079
Purity ≥98%
MDL No. MFCD01075212
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅F₂N
Molecular Weight 153.13
Synonym(s) 5,6-Difluoro-1H-indole
SMILES FC1=C(F)C=C2C(NC=C2)=C1

Computational Chemistry Data

TPSA 15.79
LogP 2.4461
H_Acceptors 0
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Key Words

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5,6-Difluoroindole

CAS No. 169674-01-5

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