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2-(6-Methoxypyridin-2-yl)acetic acid

  • CAS No. 944896-97-3

  • Cat. No. CS-0040383
  • Molecule weight167.16
  • Purity≥95%
  • MDL No.MFCD09924918

*For research and further manufacturing use only, not for direct human use.

2-(6-Methoxypyridin-2-yl)acetic acid|CS-0040383

Structure of 944896-97-3

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General Information

  • CAS No. 944896-97-3
  • Cat. No. CS-0040383
  • Purity ≥95%
  • MDL No. MFCD09924918
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight 167.16
  • Synonym(s) 6-Methoxy-2-pyridineacetic acid
  • SMILES O=C(O)CC1=NC(OC)=CC=C1

Description

This acetic acid derivative features a 6-methoxypyridin-2-yl group that enhances solubility and metabolic stability. The electron-rich pyridine ring enables efficient coupling in medicinal chemistry applications. Designed for robust performance under standard conditions, it integrates seamlessly into synthetic routes requiring polar, bench-stable intermediates.

Application

2-(6-Methoxypyridin-2-yl)acetic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyridine-based pharmacophores. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions under standard conditions. The 6-methoxy substituent enhances solubility and modulates electronic properties, while the pendant acetic acid group provides a handle for further derivatization. Bench-stable and readily purified by recrystallization, it functions effectively in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Synthesis

  • Route1
    • null|null
      1376766-14-1
    • ~49%
    • In-stock
      2-(6-Methoxypyridin-2-yl)acetic acid|CS-0040383
      944896-97-3

    References

    • Hu, Bowen; Chen, Dafa; Hu, Xile Chemistry--A European Journal, 2012 , vol. 18, # 37 p. 11528 - 11530,3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.7173
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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