2,4-Dichloro-5-fluoro-6-methylpyrimidine

CAS No. 954220-98-5
Cat. No. CS-0039159
Purity≥95%
MDL No.MFCD09863051

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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2,4-Dichloro-5-fluoro-6-methylpyrimidine|CS-0039159

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Description

2,4-Dichloro-5-fluoro-6-methylpyrimidine features a highly functionalized pyrimidine core with orthogonal halogen and methyl substituents enabling selective cross-coupling and derivatization. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and nucleoside analogs. The strategic placement of chlorine and fluorine atoms enhances reactivity while maintaining stability under standard conditions.

Application

2,4-Dichloro-5-fluoro-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution and cross-coupling reactions. The strategically positioned chlorine and fluorine atoms facilitate selective functionalization, while the methyl group enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for scalable synthesis of kinase inhibitors and other bioactive molecules.

General Information

CAS No. 954220-98-5
Cat. No. CS-0039159
Purity ≥95%
MDL No. MFCD09863051
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃Cl₂FN₂
Molecular Weight 181.00
Synonym(s) 2,4-dichloro-5-fluoro-6-methyl-pyrimidine
SMILES CC1=C(C(=NC(=N1)Cl)Cl)F

Computational Chemistry Data

TPSA 25.78
LogP 2.23092
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2,4-Dichloro-5-fluoro-6-methylpyrimidine

CAS No. 954220-98-5

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