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CS-W001157 4
Total: USD 88.00

4-methylpiperidin-4-ol Hydrochloride

  • CAS No. 586375-35-1

  • Cat. No. CS-M0531
  • Molecule weight151.63
  • Purity≥96%
  • MDL No.MFCD11044137

*For research and further manufacturing use only, not for direct human use.

4-methylpiperidin-4-ol Hydrochloride|CS-M0531

Structure of 586375-35-1

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General Information

  • CAS No. 586375-35-1
  • Cat. No. CS-M0531
  • Purity ≥96%
  • MDL No. MFCD11044137
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClNO
  • Molecular Weight 151.63
  • Synonym(s) 4-Methylpiperidin-4-ol Hydrochloride Salt
  • SMILES OC1(C)CCNCC1.Cl

Description

4-Methylpiperidin-4-ol (Hydrochloride) features a sterically hindered hydroxyl group on a saturated piperidine ring, enhancing its stability and solubility. This bench-stable, moisture-tolerant derivative serves as a key scaffold in medicinal chemistry, enabling direct incorporation into bioactive molecules via robust functionalization pathways.

Application

4-Methylpiperidin-4-ol (Hydrochloride) serves as a versatile building block in medicinal chemistry, enabling the construction of nitrogen-containing heterocycles and bioactive scaffolds. Its tertiary alcohol functionality offers reliable derivatization potential, while the protonated piperidine ring enhances solubility and stability in aqueous media. The hydrochloride salt form improves crystallinity and handling, facilitating purification and consistent performance in standard coupling and reductive alkylation protocols.

Synthesis

  • Route1

    References

    • H. LUNDBECK A/S Patent: US2011/92475 A1, 2011 ; Location in patent: Page/Page column 19 ;
  • Route2
    • 1-Benzyl-4-methylpiperidin-4-ol|CS-0279387
      3970-66-9
    • ~89%
    • In-stock
      4-methylpiperidin-4-ol Hydrochloride|CS-M0531
      586375-35-1

    References

    • EXELIXIS, INC.; RICE, Kenneth Patent: WO2012/71509 A2, 2012 ; Location in patent: Page/Page column 154 ; WO 2012/071509 A2
  • Route3
    • Benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate|CS-0049826
      169750-57-6
    • ~95%
    • In-stock
      4-methylpiperidin-4-ol Hydrochloride|CS-M0531
      586375-35-1

    References

    • Takeda Pharmaceutical Company Limited Patent: EP2392573 A1, 2011 ; Location in patent: Page/Page column 41 ;

Safety Information

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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   0.5426
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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