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Structure of 21987-29-1
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4,4-Difluoropiperidine delivers enhanced metabolic stability and altered basicity compared to piperidine, enabling strategic modulation of pharmacokinetic properties in bioactive molecule design. This difluorinated heterocycle integrates readily into medicinal chemistry scaffolds, offering improved membrane permeability and resistance to oxidative degradation under standard conditions.
4,4-Difluoropiperidine serves as a conformationally restricted bioisostere of piperidine, enabling enhanced metabolic stability and modulated basicity in medicinal chemistry applications. Its difluorinated backbone facilitates improved membrane permeability and resistance to oxidative metabolism. The compound functions as a versatile building block for constructing fluorinated heterocyclic scaffolds, with predictable reactivity in amide coupling, alkylation, and transition-metal-catalyzed transformations. Bench-stable and readily purified by distillation or chromatography, it supports scalable synthesis in API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: