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CS-W001157 4
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Ethyl 2-aminooxazole-5-carboxylate

  • CAS No. 113853-16-0

  • Cat. No. CS-W006234
  • Molecule weight156.14
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-aminooxazole-5-carboxylate|CS-W006234

Structure of 113853-16-0

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General Information

  • CAS No. 113853-16-0
  • Cat. No. CS-W006234
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O₃
  • Molecular Weight 156.14
  • Synonym(s) Ethyl 2-Amino-5-Oxazolecarboxylate
  • SMILES O=C(C1=CN=C(N)O1)OCC

Description

Ethyl 2-aminooxazole-5-carboxylate features a fused oxazole ring bearing both amino and ethyl ester functionalities, enabling direct incorporation into heterocyclic scaffolds. This bench-stable derivative serves as a key intermediate in the synthesis of bioactive oxazoles, offering enhanced solubility and reactivity in nucleophilic substitution and cyclization reactions.

Application

Ethyl 2-aminooxazole-5-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to oxazole-based scaffolds relevant to medicinal chemistry and agrochemical development. The molecule combines a readily functionalizable amino group with a carboxylate ester, facilitating nucleophilic substitution, amidation, and coupling reactions. Its bench-stable nature and compatibility with standard purification methods make it well-suited for multi-step synthetic sequences and scale-up applications.

Synthesis

  • Route1
    • null|null
      33142-21-1
    • In-stock
      Urea|CS-B1800
      57-13-6
    • ~%
    • In-stock
      Ethyl 2-aminooxazole-5-carboxylate|CS-W006234
      113853-16-0

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 10 p. 1379 - 1382

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   78.35
  • LogP   0.4335
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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