NLRP3
The NLR family pyrin domain containing protein 3 (NLRP3) inflammasome is a multimeric protein complex. Structurally, NLRP3 inflammasome contains three domains: the leucine-rich repeat-containing receptors (LRR) domain, the nucleotide-binding and oligomerization (NACHT) domain and pyrin domain (PYD). NLRP3 is a unique pattern recognition receptor (PRR) that can be widely stimulated by bacterial, viral and fungal pathogens, the environment and the host. Anomalous NLRP3 inflammasome activation has been implicated in the pathogenesis of a wide variety of human diseases and contributes to acute and chronic inflammation-associated complex diseases, including arthritis, atherosclerosis, diabetes, multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. Accordingly, inhibitors of the NLRP3 inflammasome may be useful in the treatment of these diseases.
Technical Resources
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Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiralChiral chloro-indeno pybox has served as a new ligand for the Yb(OTf)3-catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with nitroalkenes. The tunable nature of pybox ligands
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2Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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3Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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4Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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5Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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