PARP
Poly (ADP-ribose) polymerase (PARP) is a family of enzymes that play a key role in DNA repair by adding ADP-ribose units to proteins, a process essential for the repair of DNA damage. PARP1 and PARP2 are the most well-known members, involved in repairing single-strand breaks and maintaining genomic stability. Because of their role in DNA repair, PARPs have become attractive targets in cancer therapy, particularly in tumors with defects in other DNA repair mechanisms, such as BRCA1/2-mutated cancers. Inhibiting PARP can lead to synthetic lethality, selectively targeting cancer cells with impaired DNA repair.
Technical Resources
-
1
1
Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiralChiral chloro-indeno pybox has served as a new ligand for the Yb(OTf)3-catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with nitroalkenes. The tunable nature of pybox ligands
-
2Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
-
3Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
-
4Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
-
5Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
-
In-stockPurity: ≥98%
Cat. No. : CS-0041950 -
In-stockPurity: ≥95%
Cat. No. : CS-0041952 -
In-stockPurity: ≥96%
Cat. No. : CS-0120545CAS No. : 1445564-00-0* This product is not sold in the region.
-
In-stockPurity: ≥97%
Cat. No. : CS-0142500CAS No. : 1938129-80-6* This product is not sold in the region.
-
In-stockPurity: ≥95%
Cat. No. : CS-0155582 -
In-stockPurity: ≥98%
Cat. No. : CS-0197822CAS No. : 1803606-88-3* This product is not sold in the region.
-
In-stockPurity: ≥95%
Cat. No. : CS-0256030CAS No. : 2589531-74-6* This product is not sold in the region.
-
In-stockPurity: ≥95%
Cat. No. : CS-0312388 -
In-stockPurity: ≥97%
Cat. No. : CS-0378180CAS No. : 2756334-27-5* This product is not sold in the region.
-
In-stockPurity: ≥98%
Cat. No. : CS-0433946CAS No. : 2756334-26-4* This product is not sold in the region.