Ethyl 4,6-dichloronicotinate

CAS No. 40296-46-6
Cat. No. CS-W002558
Purity≥98%
MDL No.MFCD00234408

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Ethyl 4,6-dichloronicotinate is a bench-stable, moisture-tolerant ester featuring a dichlorinated pyridine core. This electron-deficient heterocycle integrates readily into synthetic sequences requiring halogen-directed functionalization. The ethyl ester group enables straightforward derivatization, streamlining access to advanced intermediates in medicinal chemistry and agrochemical development.

Application

Ethyl 4,6-dichloronicotinate serves as a versatile building block in synthetic organic chemistry, enabling the construction of substituted nicotinates and heterocyclic scaffolds. Its dual chloro groups at the 4- and 6-positions provide orthogonal sites for nucleophilic substitution, facilitating sequential functionalization. The ester functionality supports compatibility with standard coupling and reduction protocols, while the compound exhibits excellent bench stability and ease of purification—ideal for iterative synthesis in medicinal chemistry and process development workflows.

General Information

CAS No. 40296-46-6
Cat. No. CS-W002558
Purity ≥98%
MDL No. MFCD00234408
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇Cl₂NO₂
Molecular Weight 220.05
Synonym(s) None
SMILES CCOC(C1=CN=C(Cl)C=C1Cl)=O

Computational Chemistry Data

TPSA 39.19
LogP 2.5651
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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Ethyl 4,6-dichloronicotinate

CAS No. 40296-46-6

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