Cysteine Targeted Covalent Fragment Library
| Cat. No. : CS-L154 |
|---|
| （3,844） |
| Library Contents: |
| Covalent inhibitors are small molecules that can bind specifically to target proteins through covalent bonds and inhibit their biological functions. Although for a long time, covalent targeting has been playing a subordinate role in drug discovery, with an increasing number of reports on successful clinical applications of such drugs, the potential of these agents is now being acknowledged. Currently, cysteine is the most common covalent amino acid residue in a variety of covalent drugs, and various warheads have been developed that can react with cysteine, providing the key building blocks for covalent drugs to form covalent bonds. To meet the development needs of covalent inhibitors targeting cysteine, ChemScene has designed a unique collection of 3,844 fragments with different covalent warheads that target cysteine. The ChemScene Cysteine Targeted Covalent Fragment Library is designed using the following covalent warheads: Acrylamides, Propiolic acid ester, Dimethylamine functionalized acrylamides, Chloroacetamides, Acrylonitrile, 2-Cyanoacrylamide, Aziridine, Haloacetamide, etc. All fragments are pre-filtered with the Rule of Three restrictions which can be used for fragment-based covalent drug development. |
| Size (Pre-dissolved DMSO or Solid) | Stock | Price |
|---|---|---|
| In-stock | Get quote |
Products are for research use only. Not for human use. We do not sell to patients.
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Data Sheet
Description & Advantages
Composition
| Formulation: | A collection of 3,844 fragments with various warheads targeting cysteine residue supplied as pre-dissolved Solutions or Solid. |
|---|---|
| Container: | 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode. |
| Storage: | -80°C |
| Shipping: | Blue ice |
• A unique collection of 3,844 fragments with different covalent warheads that target cysteine.
• Contains various covalent warheads targeting cysteine residue.
• Compounds were pre-filtered with the Rule of Three restrictions: MW 100-300 Da, H-donors ≤3, H-acceptors ≤3 and cLogP ≤3.
• A useful tool for development covalent drugs.
• Validated NMR and HPLC to ensure high purity and quality.
• All compounds are in stock and continuously updated.
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