Boronic acid/boronic ester fragment library
| Cat. No. : CS-L924 |
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| （1,488） |
| Library Contents: |
| Boronic acid and boronic ester represent a relatively novel and promising chemical structure in drug design. Boronic acid exists in an sp²-hybridized state, possessing an empty p-orbital that can act as a Lewis acid to accept lone pairs from heteroatoms (O, N, or S). This Lewis acidity enables it to form reversible covalent bonds with amino acid residues such as lysine, serine, threonine, and histidine. Currently, five FDA-approved drugs containing boronic acid or boronic ester predominantly involve such covalent binding mechanisms in their interactions with target proteins. Furthermore, boronic acid can serve as a bioisostere for carboxylic acids, phosphates, and phenolic groups, utilized to improve pharmacokinetic properties and enhance drug efficacy. To date, five boron-containing drugs have been approved by the FDA. The unique properties of boronic acids and boronic esters confer significant potential in drug design, with applications spanning cancer therapy (e.g., multiple myeloma), anti-infectives (e.g., fungal infections, tuberculosis), anti-inflammatory treatments (e.g., atopic dermatitis), antibacterial agents (e.g., carbapenem-resistant bacterial infections), and Reactive Oxygen Species (ROS)-responsive prodrugs, among others. The ChemScene Boronic Acid/Boronic Ester Fragment Library, which contains 1,488 compounds, serves as a valuable tool for the development of boron-containing drugs. |
| Size (Pre-dissolved DMSO or Solid) | Stock | Price |
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| In-stock | Get quote |
Products are for research use only. Not for human use. We do not sell to patients.
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Data Sheet
Description & Advantages
Composition
| Formulation: | 1,488 boronic acid or boronic ester compounds obtained through substructure search, making it a valuable tool for the discovery of boron-containing drugs. |
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| Container: | 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode. |
| Storage: | -80°C |
| Shipping: | Blue ice or dry ice |
• A unique collection of 1,488 boronic acid/boronic ester fragment compounds is available for high throughput screening (HTS) and high content screening (HCS).
• All compounds are screened using substructure search.
• All compounds are available off the shelf.
• LCMS or NMR validated to ensure high purity and quality.
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