Chiral Compound Screening Library
| Cat. No. : CS-L952 |
|---|
| （11059） |
| Library Contents: |
| Chirality can significantly influence drug–target affinity, subtype selectivity, and toxicological profiles. The thalidomide tragedy highlights the profound biological consequences of stereochemistry, making stereochemical evaluation essential in early drug discovery. Three Nobel Prizes in Chemistry—in 2001, 2021, and 2026—have advanced our understanding of chirality, from asymmetric catalysis and stereoselective synthesis to asymmetric autocatalysis and nonlinear effects that explain the propagation and amplification of chiral signals. Enantiomers (R/S) can exhibit distinct target-binding affinities, subtype selectivity, and pharmacokinetic properties. This library supports enantiomer-specific binding studies using affinity selection–mass spectrometry (AS-MS) and other screening platforms. Library Highlights: Comprising 2,792 structurally diverse small molecules, the library offers broad chemical space coverage and lead-like physicochemical properties. It supports high-throughput screening across therapeutic targets, hit identification, and preliminary structure–activity relationship (SAR) studies. Complementary stereochemical characterization services facilitate seamless integration into lead optimization programs. |
| Size (Pre-dissolved DMSO or Solid) | Stock | Price |
|---|---|---|
| In-stock | Get quote |
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Data Sheet
Description & Advantages
Composition
| Formulation: | Lead-like screening library for diverse targets and platforms, featuring single-stereocenter compounds. |
|---|---|
| Container: | 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode. |
| Storage: | -80°C |
| Shipping: | Blue ice or dry ice |
• Specialized 1,0000+ Compound Lead-Like Screening Library for Diverse Target-Binding and Enantioselectivity Studies.
• Each compound contains a single stereocenter; stereochemical characterization is not performed during library production.
• Computationally curated lead like physicochemical properties support hit discovery across diverse targets.
• All compounds are available off the shelf.
• All compounds are validated by LC-MS or NMR to ensure high purity and quality.
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