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Structure of 1001020-14-9
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3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde features a trifluoromethyl group flanking an aldehyde-functionalized pyrazole core, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables efficient coupling in transition-metal-catalyzed transformations and facilitates incorporation into bioactive scaffolds requiring polar, lipophilic moieties. The molecule exhibits robust bench stability under standard conditions, simplifying handling in synthetic workflows.
3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a trifluoromethyl group adjacent to a reactive aldehyde for downstream functionalization. The aldehyde functionality facilitates efficient reductive amination, condensation, and coupling reactions, while the pyrazole core provides metabolic stability and hydrogen-bonding capacity. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step synthesis workflows targeting bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: