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Structure of 318951-60-9
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3-(Trifluoromethyl)-1H-pyrazole-4-carbonitrile features a trifluoromethyl group and a nitrile moiety positioned ortho to each other on the pyrazole ring, creating a highly electron-deficient heterocyclic scaffold. This combination enhances its utility in medicinal chemistry and materials science, where strong dipole moments and metabolic stability are advantageous. The molecule exhibits bench-stable handling characteristics and integrates readily into complex synthetic sequences.
3-(Trifluoromethyl)-1H-pyrazole-4-carbonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via standard coupling reactions. Its trifluoromethyl and nitrile groups provide enhanced metabolic stability and favorable electronic properties, while maintaining bench stability and compatibility with common functional group manipulations. The molecule functions effectively in palladium-catalyzed cross-couplings and nucleophilic substitutions, facilitating rapid access to diverse analogs for drug discovery campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: