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Structure of 1003845-08-6
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2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine delivers a boronate handle at the pyrimidine C5 position, enabling efficient Suzuki-Miyaura coupling under standard conditions. The tetramethyl-substituted dioxaborolane moiety enhances stability and moisture tolerance, while the chloropyrimidine electrophile supports selective cross-coupling in complex molecular architectures.
2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine serves as a versatile boron-containing building block for palladium-catalyzed cross-coupling reactions. The pyrimidine core provides a stable heterocyclic scaffold with predictable reactivity, while the pinacol boronate group enables efficient coupling with aryl, vinyl, and heteroaryl halides under mild conditions. Bench-stable and readily purified by flash chromatography, it facilitates the construction of complex pharmaceutical intermediates and functionalized heterocycles in high yield.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: