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CS-W001157 4
Total: USD 88.00

(3-((Trimethylsilyl)ethynyl)phenyl)methanol

  • CAS No. 1007587-63-4

  • Cat. No. CS-0608565
  • Molecule weight204.34
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-((Trimethylsilyl)ethynyl)phenyl)methanol|CS-0608565

Structure of 1007587-63-4

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General Information

  • CAS No. 1007587-63-4
  • Cat. No. CS-0608565
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆OSi
  • Molecular Weight 204.34
  • Synonym(s) None
  • SMILES OCC1=CC=CC(C#C[Si](C)(C)C)=C1

Description

This trimethylsilyl-protected alkyne-bearing phenylmethanol features a reactive terminal alkyne flanked by a hydroxymethyl group, enabling seamless incorporation into Sonogashira couplings and subsequent desilylation. The silyl ether moiety confers enhanced stability and solubility in organic media, simplifying handling and purification under standard conditions.

Application

(3-((Trimethylsilyl)ethynyl)phenyl)methanol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized aryl alkynes. The trimethylsilyl group provides excellent stability and orthogonality, facilitating selective deprotection and downstream coupling reactions. Its terminal alkyne functionality readily participates in copper-catalyzed azide-alkyne cycloadditions (CuAAC), while the pendant alcohol allows for derivatization or protection. This compound exhibits good bench stability, ease of purification, and compatibility with standard reaction conditions, making it well-suited for medicinal chemistry and materials synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.4078
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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