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CS-W001157 4
Total: USD 88.00

4,5-Dichloropyridine-3-carbaldehyde

  • CAS No. 1009334-04-6

  • Cat. No. CS-0051112
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,5-Dichloropyridine-3-carbaldehyde|CS-0051112

Structure of 1009334-04-6

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General Information

  • CAS No. 1009334-04-6
  • Cat. No. CS-0051112
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃Cl₂NO
  • Molecular Weight 176.00
  • Synonym(s) 4,5-dichloro-3-Pyridinecarboxaldehyde
  • SMILES ClC1=CN=CC(C=O)=C1Cl

Description

4,5-Dichloropyridine-3-carbaldehyde features a pyridine core functionalized with two chlorine atoms and a formyl group at the 3-position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct coupling reactions and facilitating the synthesis of bioactive compounds through its reactive aldehyde handle.

Application

4,5-Dichloropyridine-3-carbaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. The aldehyde functionality enables efficient imine formation, reductive amination, and Suzuki-Miyaura coupling, while the dichloro substituents provide orthogonal reactivity for late-stage functionalization. Its bench-stable nature and compatibility with diverse reaction conditions facilitate streamlined access to complex pyridine-based scaffolds.

Synthesis

  • Route1
    • In-stock
      3,4-Dichloropyridine|CS-W004811
      55934-00-4
    • null|null
      68-12-2
    • ~68%
    • In-stock
      4,5-Dichloropyridine-3-carbaldehyde|CS-0051112
      1009334-04-6

    References

    • F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; GOODACRE, Simon; LAI, Yingjie; LIANG, Yun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong Patent: WO2012/66061 A1, 2012 ; Location in patent: Page/Page column 122 ; WO 2012/066061 A1
  • Route2
    • null|null
      68-12-2
    • ~64%
    • In-stock
      4,5-Dichloropyridine-3-carbaldehyde|CS-0051112
      1009334-04-6

    References

    • GENENTECH, INC. Patent: WO2008/24725 A1, 2008 ; Location in patent: Page/Page column 85 ; WO 2008/024725 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.2009
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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