Fmoc-Phe-OSu

Name: Fmoc-Phe-OSu
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 101214-43-1
Cat. No. CS-0149751
Purity≥95%
MDL No.MFCD00062204

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 101214-43-1

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General Information

CAS No. 101214-43-1
Cat. No. CS-0149751
Purity ≥95%
MDL No. MFCD00062204
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₈H₂₄N₂O₆
Molecular Weight 484.50
Synonym(s) None
SMILES O=C(ON1C(CCC1=O)=O)[C@@H](NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)CC5=CC=CC=C5

Description

Fmoc-Phe-OSu delivers a protected phenylalanine residue with high reactivity for peptide coupling. The Fmoc group enables efficient orthogonal deprotection, while the OSu ester facilitates rapid amide bond formation under mild conditions. This reagent integrates seamlessly into solid-phase synthesis workflows, offering reliable incorporation with minimal racemization.

Application

Fmoc-Phe-OSu serves as a robust amino acid derivative for solid-phase peptide synthesis, enabling efficient coupling of phenylalanine residues under mild conditions. The Fmoc group provides orthogonal protection, while the OSu (N-hydroxysuccinimide ester) moiety ensures high reactivity with primary amines. Its stability in storage and ease of purification make it ideal for routine use in peptide assembly workflows.

Synthesis

Route1
- In-stock
  
  74124-79-1
- In-stock
  
  35661-40-6
- ~%
- In-stock
  
  101214-43-1
References
- Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 20 p. 5559 - 5562
Route2
- In-stock
  
  6066-82-6
- In-stock
  
  35661-40-6
- ~97%
- In-stock
  
  101214-43-1
References
- Journal of Pharmaceutical Sciences, , vol. 83, # 7 p. 999 - 1005

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 102.01
LogP 3.7436
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 7

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-Phe-OSu

CAS No. 101214-43-1

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