2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Name: 2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Brand: ChemScene
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CAS No. 1013916-37-4
Cat. No. CS-B0328
Purity≥96%
MDL No.MFCD13181207

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one|CS-B0328

Structure of 1013916-37-4

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Description

2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one features a sterically encumbered cyclopentyl group and electron-deficient pyrimidine core, enabling selective engagement in kinase inhibition. The 2-chloro substituent enhances reactivity for downstream derivatization, while the methyl and carbonyl functionalities stabilize the tautomeric form under standard conditions. This scaffold integrates readily into bioactive molecule design.

Application

2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one serves as a versatile scaffold for medicinal chemistry campaigns, enabling efficient construction of purine-like heterocycles. The chloro group at C2 facilitates nucleophilic substitution reactions, while the 5-methyl and 8-cyclopentyl substituents provide steric and electronic modulation. This compound exhibits bench stability and compatibility with standard coupling conditions, making it well-suited for parallel synthesis and lead optimization workflows.

General Information

CAS No. 1013916-37-4
Cat. No. CS-B0328
Purity ≥96%
MDL No. MFCD13181207
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₄ClN₃O
Molecular Weight 263.72
Synonym(s) Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-chloro-8-cyclopentyl-5-methyl-
SMILES O=C1N(C2CCCC2)C3=NC(Cl)=NC=C3C(C)=C1

Computational Chemistry Data

TPSA 47.78
LogP 2.86842
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

CAS No. 1013916-37-4

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