tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

Name: tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 571188-59-5
Cat. No. CS-B0332
Purity≥98%
MDL No.MFCD11594962

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate|CS-B0332

Structure of 571188-59-5

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Description

tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate features a piperazine scaffold linked to a 6-aminopyridin-3-yl moiety, enabling direct functionalization at the pyridine nitrogen. This bench-stable, moisture-tolerant building block integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds. The tert-butyl ester group facilitates selective deprotection under mild acidic conditions, streamlining downstream conjugation.

Application

tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate serves as a versatile building block for the synthesis of pyridine-containing pharmaceuticals and agrochemicals. The protected amine enables orthogonal functionalization, while the piperazine core facilitates hydrogen bonding and solubility enhancement in drug candidates. It reacts readily in standard coupling and cyclization protocols, offering high bench stability and ease of purification.

General Information

CAS No. 571188-59-5
Cat. No. CS-B0332
Purity ≥98%
MDL No. MFCD11594962
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₂N₄O₂
Molecular Weight 278.36
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CCN(C2=CC=C(N=C2)N)CC1

Computational Chemistry Data

TPSA 71.69
LogP 1.7209
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

CAS No. 571188-59-5

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