1-(6-bromo-3-fluoropyridin-2-yl)ethan-1-one

Name: 1-(6-bromo-3-fluoropyridin-2-yl)ethan-1-one
Brand: ChemScene
Availability: InStock
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CAS No. 1016228-01-5
Cat. No. CS-W000628
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(6-bromo-3-fluoropyridin-2-yl)ethan-1-one|CS-W000628

Structure of 1016228-01-5

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Description

1-(6-Bromo-3-fluoropyridin-2-yl)ethan-1-one features a bromo-fluoro-substituted pyridine core paired with an acetyl group, delivering a robust scaffold for late-stage functionalization. This electron-deficient heterocycle integrates seamlessly into cross-coupling reactions and enables efficient access to complex pharmaceutical intermediates under standard conditions.

Application

1-(6-Bromo-3-fluoropyridin-2-yl)ethan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The ortho-bromo and meta-fluoro substituents provide complementary reactivity for sequential derivatization, while the acetyl group offers a handle for further transformations such as enolization or nucleophilic substitution. Its bench-stable nature and compatibility with standard synthetic workflows make it ideal for constructing complex heterocyclic scaffolds and API intermediates.

General Information

CAS No. 1016228-01-5
Cat. No. CS-W000628
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅BrFNO
Molecular Weight 218.02
Synonym(s) 1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone
SMILES Brc1ccc(c(n1)C(=O)C)F

Computational Chemistry Data

TPSA 29.96
LogP 2.1858
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Ketone

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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1-(6-bromo-3-fluoropyridin-2-yl)ethan-1-one

CAS No. 1016228-01-5

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