Lot numbers can be found on the outside label of a product:
1-tert-Butyl 4-ethyl 4-(aminomethyl)piperidine-1,4-dicarboxylate
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CAS No. 1016258-69-7
- Cat. No. CS-0052362
- Purity≥95%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 1016258-69-7
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General Information
- CAS No. 1016258-69-7
- Cat. No. CS-0052362
- Purity ≥95%
- MDL No. None
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₄H₂₆N₂O₄
- Molecular Weight 286.37
- Synonym(s) 1-tert-Butyl 4-ethyl 4-(aminomethyl)-piperidine-1,4-dicarboxylate hydrochloride
- SMILES CCOC(=O)C1(CN)CCN(CC1)C(=O)OC(C)(C)C
Description
1-tert-Butyl 4-ethyl 4-(aminomethyl)piperidine-1,4-dicarboxylate is a bench-stable piperidine derivative featuring orthogonal functional handles: a protected amine and an ester group. This scaffold integrates seamlessly into late-stage diversification strategies, enabling direct coupling with electrophiles or selective deprotection under mild conditions. The tert-butyl and ethyl esters provide enhanced solubility and stability during synthetic manipulations.
Application
1-tert-Butyl 4-ethyl 4-(aminomethyl)piperidine-1,4-dicarboxylate serves as a versatile bis-protected piperidine building block, enabling efficient access to complex nitrogen-containing scaffolds. The tert-butyl and ethyl ester groups provide orthogonal protection for amine and carboxylic acid functionalities, facilitating sequential deprotection and functionalization. Its aminomethyl side chain offers a direct handle for further derivatization via alkylation, acylation, or coupling reactions, making it particularly valuable in medicinal chemistry campaigns requiring modular heterocyclic synthesis.
Synthesis
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Route1
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1016258-66-4 - ~83%
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In-stock
1016258-69-7
References
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ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2009/47563 A1, 2009 ; Location in patent: Page/Page column 88 ; WO 2009/047563 A1
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Route2
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In-stock
4395-98-6 - ~%
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In-stock
1016258-69-7
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5910 - 5915
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Route3
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In-stock
24424-99-5 - ~%
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In-stock
1016258-69-7
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5910 - 5915
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 81.86
- LogP 1.5255
- H_Acceptors 5
- H_Donors 1
- Rotatable_Bonds 3
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Key Words
- 1016258-69-7 sigma1016258-69-7 manufacturer1016258-69-7 price1016258-69-7 structure1016258-69-7 SDSbuy 1016258-69-71016258-69-7 supplier1016258-69-7 uses1016258-69-7 molecular weightprice of 1016258-69-71016258-69-7 chemical name formula of 1016258-69-7