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Structure of 1017793-20-2
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2,5-Difluoro-4-iodopyridine delivers a strategically fluorinated and iodinated pyridine scaffold ideal for cross-coupling transformations. The electron-deficient ring pairs with the reactive iodide for efficient Pd-catalyzed bond formation, while the difluoro substitution enhances metabolic stability and modulates electronic properties in bioactive molecule synthesis.
2,5-Difluoro-4-iodopyridine serves as a versatile building block in cross-coupling chemistry, enabling the construction of fluorinated heterocyclic scaffolds common in pharmaceutical development. The iodine substituent facilitates reliable Suzuki, Stille, and Negishi couplings, while the difluoro groups enhance metabolic stability and modulate electronic properties. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis and late-stage functionalization in medicinal chemistry workflows.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: