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Structure of 19094-56-5
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2-Chloro-5-iodobenzoic acid features a benzene ring bearing chlorine and iodine substituents at ortho and para positions relative to the carboxylic acid group. This electronic asymmetry enhances reactivity in cross-coupling transformations, while the carboxylic acid facilitates direct derivatization. The molecule exhibits robust stability under standard handling conditions and serves as a key intermediate for functionalized aromatic systems in medicinal chemistry and materials science.
2-Chloro-5-iodobenzoic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its orthogonal halogen reactivity—chlorine at C2 and iodine at C5—facilitates sequential functionalization, while the carboxylic acid group supports direct derivatization or metal salt formation. The compound exhibits excellent bench stability and compatibility with standard purification protocols, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS05,GHS06,GHS09
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H318-H400
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Precautionary Statements : P264-P270-P273-P280-P330-P391-P405-P501
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Lot numbers can be found on the outside label of a product: