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Structure of 101975-23-9
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This ketone features a difluoromethoxy group attached to a phenyl ring, enhancing electron-withdrawing character and metabolic stability. The acetyl side chain provides a reactive carbonyl for nucleophilic addition or conjugate addition. This scaffold serves as a key building block in medicinal chemistry, particularly for targeting CNS-penetrant molecules and bioactive heterocycles.
1-(3-(Difluoromethoxy)phenyl)ethan-1-one serves as a versatile aryl ketone building block for medicinal chemistry and materials synthesis. Its difluoromethoxy substituent enhances metabolic stability and modulates lipophilicity, while the acetyl group enables straightforward functionalization via nucleophilic addition, enolization, or coupling reactions. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: