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CS-W001157 4
Total: USD 88.00

4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 1020056-56-7

  • Cat. No. CS-0037735
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine|CS-0037735

Structure of 1020056-56-7

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Description

4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine is a heteroaromatic scaffold featuring a chlorine substituent at the 4-position and a methyl group at the 5-position, conferring enhanced electron-withdrawing character and improved solubility. This robust core integrates readily into medicinal chemistry libraries, enabling efficient access to kinase inhibitors and targeted therapeutics through Suzuki-Miyaura coupling and other cross-coupling protocols under standard conditions.

Application

4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of kinase inhibitors and other bioactive scaffolds. Its defined regiochemistry and compatibility with palladium-catalyzed cross-coupling reactions facilitate rapid diversification. The chloro group provides a reliable handle for nucleophilic substitution, while the methyl substituent enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development.

General Information

  • CAS No. 1020056-56-7
  • Cat. No. CS-0037735
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClN₂
  • Molecular Weight 166.61
  • Synonym(s) None
  • SMILES CC1=CNC2=NC=CC2=C1Cl

Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.47632
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P305+P351+P338-P330-P501

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