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Structure of 1020056-56-7
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4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine is a heteroaromatic scaffold featuring a chlorine substituent at the 4-position and a methyl group at the 5-position, conferring enhanced electron-withdrawing character and improved solubility. This robust core integrates readily into medicinal chemistry libraries, enabling efficient access to kinase inhibitors and targeted therapeutics through Suzuki-Miyaura coupling and other cross-coupling protocols under standard conditions.
4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of kinase inhibitors and other bioactive scaffolds. Its defined regiochemistry and compatibility with palladium-catalyzed cross-coupling reactions facilitate rapid diversification. The chloro group provides a reliable handle for nucleophilic substitution, while the methyl substituent enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P264-P270-P280-P305+P351+P338-P330-P501
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Lot numbers can be found on the outside label of a product: