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tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride

  • CAS No. 1023301-84-9

  • Cat. No. CS-D0628
  • Purity≥98%
  • MDL No.MFCD13185086

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride|CS-D0628

Structure of 1023301-84-9

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General Information

  • CAS No. 1023301-84-9
  • Cat. No. CS-D0628
  • Purity ≥98%
  • MDL No. MFCD13185086
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₃ClN₂O₂
  • Molecular Weight 262.78
  • Synonym(s) None
  • SMILES O=C(N1CCC2(CC1)CNC2)OC(C)(C)C.Cl

Description

tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride features a rigid spirocyclic scaffold with two nitrogen atoms at strategic positions, enabling efficient incorporation into bioactive molecules. The protonated amine enhances solubility and facilitates salt formation, while the tert-butyl ester group provides stability and convenient deprotection under mild acidic conditions. This combination supports streamlined synthesis in medicinal chemistry campaigns.

Application

tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride serves as a versatile spirocyclic scaffold for medicinal chemistry and catalytic synthesis. The protected diamine functionality enables selective derivatization, while the tert-butyl ester facilitates straightforward deprotection under mild acidic conditions. Its stability, solubility in common organic solvents, and compatibility with diverse reaction conditions make it ideal for iterative synthesis of complex nitrogen-containing architectures.

Synthesis

  • Route1
    • Tert-butyl 4-cyano-4-((tosyloxy)methyl)piperidine-1-carboxylate|CS-0541028
      929302-00-1
    • ~%
    • In-stock
      tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride|CS-D0628
      1023301-84-9

    References

    • WO2007/30061 A1, ; Page/Page column 92; 93 ; WO 2007/030061 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   2.0287
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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