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Structure of 10242-00-9
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6-Nitro-1H-indole-2-carboxylic acid features a nitro group at the 6-position and a carboxylic acid at the 2-position, creating a highly electron-deficient indole scaffold. This combination enables direct functionalization in C–H activation reactions and facilitates conjugation to biomolecules via amide coupling. The molecule exhibits enhanced solubility in polar solvents compared to non-substituted analogs, streamlining purification and handling in synthetic workflows.
6-Nitro-1H-indole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position via standard carboxylic acid transformations. Its electron-deficient indole core enhances reactivity in nucleophilic substitution and transition-metal-catalyzed coupling reactions. The nitro group provides orthogonal handle for selective reduction or further derivatization, while the bench-stable, crystalline nature facilitates straightforward isolation and purification.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: