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Structure of 10242-02-1
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5-Methyl-1H-indole-3-carboxylic acid integrates a methyl group at the 5-position of the indole core, enhancing electron density and metabolic stability. This substitution pattern supports improved solubility in organic solvents and facilitates direct coupling in peptide and heterocyclic syntheses. The carboxylic acid moiety enables straightforward derivatization for bioconjugation or polymer functionalization.
5-Methyl-1H-indole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive heterocycles. Its carboxylic acid group facilitates amide coupling and esterification under standard conditions, while the methyl substituent enhances metabolic stability. The indole core provides a rigid, planar scaffold suitable for target-directed synthesis, with demonstrated utility in constructing kinase inhibitors and GPCR ligands. Bench-stable and readily purified by recrystallization, it supports scalable workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: