1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid

Name: 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid
Brand: ChemScene
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CAS No. 10250-64-3
Cat. No. CS-W000421
Purity≥97%
MDL No.MFCD08271939

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid|CS-W000421

Structure of 10250-64-3

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Description

1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid features a conjugated pyrazole core with orthogonal phenyl and carboxylic acid functionalities, enabling integration into bioactive scaffolds. The electron-deficient pyrazole ring enhances reactivity in coupling processes, while the methyl group improves solubility and metabolic stability. This compound serves as a key intermediate for pharmaceuticals and agrochemicals requiring heterocyclic diversity.

Application

1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization reactions. Its robust bench stability, combined with orthogonal reactivity of the carboxylic acid and pyrazole core, facilitates efficient derivatization and purification. This compound functions effectively in peptide coupling, amide formation, and transition-metal-catalyzed transformations, supporting scalable route development for API candidates.

General Information

CAS No. 10250-64-3
Cat. No. CS-W000421
Purity ≥97%
MDL No. MFCD08271939
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₀N₂O₂
Molecular Weight 202.21
Synonym(s) 5-Carboxy-1-methyl-3-phenyl-1H-pyrazole
SMILES CN1C(C(O)=O)=CC(C2=CC=CC=C2)=N1

Computational Chemistry Data

TPSA 55.12
LogP 1.7853
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid

CAS No. 10250-64-3

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