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CS-W001157 4
Total: USD 88.00

2-Methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine

  • CAS No. 1026-05-7

  • Cat. No. CS-0137222
  • Purity≥95%
  • MDL No.MFCD00183927

*For research and further manufacturing use only, not for direct human use.

2-Methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine|CS-0137222

Structure of 1026-05-7

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General Information

  • CAS No. 1026-05-7
  • Cat. No. CS-0137222
  • Purity ≥95%
  • MDL No. MFCD00183927
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₈N₂
  • Molecular Weight 238.33
  • Synonym(s) (2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE
  • SMILES CC1NC2=C(C=CC=C2)C(NC3=CC=CC=C3)C1

Description

2-Methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine is a sterically hindered, bench-stable heterocyclic amine featuring a fused tetrahydroquinoline core with a methyl group at the 2-position and a phenyl substituent on nitrogen. This configuration enhances solubility and stability under standard conditions, enabling efficient incorporation into pharmaceutical intermediates and functional materials through coupling reactions.

Application

2-Methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine serves as a versatile building block in medicinal chemistry, enabling access to diverse heterocyclic scaffolds through standard functional group manipulations. Its structural motif combines a substituted tetrahydroquinoline core with an aniline-like nitrogen, offering favorable reactivity for further derivatization. The compound exhibits good bench stability and facilitates efficient coupling reactions, making it well-suited for iterative synthesis campaigns targeting bioactive molecules.

Synthesis

  • Route1
    • null|null
      2028-84-4
    • null|null
      75-07-0
    • null|null
      74497-02-2
    • ~43%
    • In-stock
      2-Methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine|CS-0137222
      1026-05-7
    • null|null
      33863-77-3

    References

    • Clerici; Porta Tetrahedron Letters, 1990 , vol. 31, # 14 p. 2069 - 2072
  • Route2
    • 4-Methoxybenzenediazonium chloride|CS-0925990
      4346-59-2
    • null|null
      75-07-0
    • null|null
      74497-02-2
    • ~39%
    • In-stock
      2-Methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine|CS-0137222
      1026-05-7
    • In-stock
      N-(4-Methoxybenzyl)-4-methylaniline|CS-1056590
      112825-69-1

    References

    • Clerici; Porta Tetrahedron Letters, 1990 , vol. 31, # 14 p. 2069 - 2072
  • Route3
    • Edaravone Impurity 1|CS-1000126
      100-34-5
    • null|null
      75-07-0
    • null|null
      74497-02-2
    • ~34%
    • In-stock
      2-Methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine|CS-0137222
      1026-05-7
    • N-(1-Phenylethyl)aniline|CS-0250760
      779-54-4

    References

    • Clerici; Porta Tetrahedron Letters, 1990 , vol. 31, # 14 p. 2069 - 2072

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.06
  • LogP   4.0439
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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