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Structure of 10300-27-3
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3'-O-Methylguanosine is a modified nucleoside featuring a methyl group at the 3' hydroxyl position of the ribose sugar. This modification enhances metabolic stability and resistance to enzymatic degradation, making it valuable for probing RNA structure-function relationships and developing nuclease-resistant oligonucleotide therapeutics.
3'-O-Methylguanosine serves as a key nucleoside building block for the synthesis of modified RNA oligonucleotides, enabling site-specific incorporation of methylated 3'-end functionalities. Its stability under standard coupling conditions and compatibility with solid-phase synthesis protocols facilitate efficient access to epigenetically relevant RNA analogs. The methyl group at the 3'-oxygen position enhances nuclease resistance, supporting applications in antisense therapeutics and functional RNA studies.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: