Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3'-O-Methylguanosine

  • CAS No. 10300-27-3

  • Cat. No. CS-0137787
  • Molecule weight297.27
  • Purity≥98%
  • MDL No.MFCD00057057

*For research and further manufacturing use only, not for direct human use.

3'-O-Methylguanosine|CS-0137787

Structure of 10300-27-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 10300-27-3
  • Cat. No. CS-0137787
  • Purity ≥98%
  • MDL No. MFCD00057057
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅N₅O₅
  • Molecular Weight 297.27
  • Synonym(s) None
  • SMILES O[C@@H]1[C@H](OC)[C@@H](CO)O[C@H]1N2C=NC3=C2NC(N)=NC3=O

Description

3'-O-Methylguanosine is a modified nucleoside featuring a methyl group at the 3' hydroxyl position of the ribose sugar. This modification enhances metabolic stability and resistance to enzymatic degradation, making it valuable for probing RNA structure-function relationships and developing nuclease-resistant oligonucleotide therapeutics.

Application

3'-O-Methylguanosine serves as a key nucleoside building block for the synthesis of modified RNA oligonucleotides, enabling site-specific incorporation of methylated 3'-end functionalities. Its stability under standard coupling conditions and compatibility with solid-phase synthesis protocols facilitate efficient access to epigenetically relevant RNA analogs. The methyl group at the 3'-oxygen position enhances nuclease resistance, supporting applications in antisense therapeutics and functional RNA studies.

Synthesis

  • Route1

    References

    • Yamauchi, Kiyoshi; Nakagima, Toru; Kinoshita, Masayoshi Journal of Organic Chemistry, 1980 , vol. 45, # 19 p. 3865 - 3868
  • Route2
    • 2-Amino-3’-O-methyladenosine|CS-0640467
      80791-88-4
    • ~91%
    • In-stock
      3'-O-Methylguanosine|CS-0137787
      10300-27-3

    References

    • Robins, Morris J.; Hansske, Fritz; Bernier, Salwa E. Canadian Journal of Chemistry, 1981 , vol. 59, p. 3360 - 3364
  • Route3

    References

    • Yamauchi, Kiyoshi; Nakagima, Toru; Kinoshita, Masayoshi Journal of Organic Chemistry, 1980 , vol. 45, # 19 p. 3865 - 3868

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   148.51
  • LogP   -2.0326
  • H_Acceptors   9
  • H_Donors   4
  • Rotatable_Bonds   3

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3'-O-Methylguanosine sigma3'-O-Methylguanosine manufacturer3'-O-Methylguanosine price3'-O-Methylguanosine structure3'-O-Methylguanosine SDSbuy 3'-O-Methylguanosine3'-O-Methylguanosine supplier3'-O-Methylguanosine uses3'-O-Methylguanosine molecular weightprice of 3'-O-Methylguanosine3'-O-Methylguanosine chemical name formula of 3'-O-Methylguanosine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label