3-Chloro-1H-pyrazol-4-amine

Name: 3-Chloro-1H-pyrazol-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 103286-54-0
Cat. No. CS-W007071
Purity≥95%
MDL No.MFCD23701740

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 103286-54-0

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General Information

CAS No. 103286-54-0
Cat. No. CS-W007071
Purity ≥95%
MDL No. MFCD23701740
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₄ClN₃
Molecular Weight None
Synonym(s) 5-chloro-1H-pyrazol-4-amine
SMILES NC1=CNN=C1Cl

Description

3-Chloro-1H-pyrazol-4-amine features a chlorinated pyrazole core with a primary amine at the 4-position, enabling direct incorporation into diverse heterocyclic scaffolds. This bench-stable, moisture-tolerant building block facilitates efficient access to bioactive compounds through coupling reactions and nucleophilic substitution processes.

Application

3-Chloro-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazole-based heterocycles. Its chloro and amino groups offer orthogonal reactivity for C–H functionalization, Suzuki-Miyaura coupling, or amide formation. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns and API intermediate development.

Synthesis

Route1
- In-stock
  
  2075-46-9
- ~%
- In-stock
  
  103286-54-0
References
- CELLZOME LIMITED; RAMSDEN, Nigel; HARRISON, Richard John; OXENFORD, Sally; BELL, Kathryn; PITON, Nelly; DAGOSTIN, Claudio; BOUSSARD, Cyrille; RATCLIFFE, Andrew Patent: WO2011/48082 A1, 2011 ; Location in patent: Page/Page column 115 ; WO 2011/048082 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 54.7
LogP 0.6453
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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3-Chloro-1H-pyrazol-4-amine

CAS No. 103286-54-0

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