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CS-W001157 4
Total: USD 88.00

4-Bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine

  • CAS No. 1032943-41-1

  • Cat. No. CS-0044863
  • Purity≥98%
  • MDL No.MFCD16250453

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine|CS-0044863

Structure of 1032943-41-1

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General Information

  • CAS No. 1032943-41-1
  • Cat. No. CS-0044863
  • Purity ≥98%
  • MDL No. MFCD16250453
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrN₃
  • Molecular Weight 212.05
  • Synonym(s) None
  • SMILES CN1N=CC2=C1C=NC=C2Br

Description

4-Bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine is a heterocyclic scaffold featuring a brominated pyrazolopyridine core with a methyl group at the 1-position. This electron-deficient system integrates readily into cross-coupling reactions and serves as a key building block for bioactive molecules in medicinal chemistry. The bromo substituent enables precise functionalization under palladium-catalyzed conditions.

Application

4-Bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and catalytic cross-coupling applications. Its bromine substituent enables reliable Suzuki, Stille, and Buchwald-Hartwig couplings, while the methyl group enhances solubility and metabolic stability. The pyrazolopyridine core provides a rigid, planar scaffold with favorable electronic properties for drug discovery. Bench-stable and readily purified by flash chromatography, it functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive compounds.

Synthesis

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      1032943-36-4
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    • In-stock
      4-Bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine|CS-0044863
      1032943-41-1

    References

    • EP1932845 A1, ; Page/Page column 30; 32-33 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.71
  • LogP   1.7308
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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