4-Bromo-5-methylpyridin-2-amine

Name: 4-Bromo-5-methylpyridin-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1033203-32-5
Cat. No. CS-0127936
Purity≥97%
MDL No.MFCD11100640

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Bromo-5-methylpyridin-2-amine|CS-0127936

Structure of 1033203-32-5

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Description

4-Bromo-5-methylpyridin-2-amine features a pyridine core functionalized with bromo and methyl groups at adjacent positions, enabling selective cross-coupling reactions. The electron-deficient nitrogen atom facilitates metal coordination, while the para-arranged substituents provide steric and electronic control. This scaffold integrates readily into bioactive heterocycles and serves as a key intermediate in medicinal chemistry.

Application

4-Bromo-5-methylpyridin-2-amine serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its bromo group enables palladium-catalyzed cross-coupling reactions, while the pyridin-2-amine functionality offers sites for further functionalization via electrophilic substitution or metal complexation. The methyl substituent enhances solubility and modulates electronic properties, contributing to improved stability and reactivity in standard synthetic workflows.

General Information

CAS No. 1033203-32-5
Cat. No. CS-0127936
Purity ≥97%
MDL No. MFCD11100640
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇BrN₂
Molecular Weight 187.04
Synonym(s) 4-Bromo-5-methyl-pyridin-2-ylamine
SMILES NC1=NC=C(C)C(Br)=C1

Computational Chemistry Data

TPSA 38.91
LogP 1.73472
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Bromo-5-methylpyridin-2-amine

CAS No. 1033203-32-5

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