2-Bromo-4-chloro-5-fluoropyridine

Name: 2-Bromo-4-chloro-5-fluoropyridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1033203-44-9
Cat. No. CS-0146033
Purity≥95%
MDL No.MFCD11100658

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Bromo-4-chloro-5-fluoropyridine|CS-0146033

Structure of 1033203-44-9

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Description

2-Bromo-4-chloro-5-fluoropyridine is a halogenated pyridine derivative featuring strategically positioned bromo, chloro, and fluoro substituents. This combination imparts enhanced reactivity in cross-coupling processes while maintaining stability under standard conditions. The electron-deficient ring system facilitates nucleophilic substitution and enables efficient integration into pharmaceutical intermediates and advanced functional materials.

Application

2-Bromo-4-chloro-5-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The strategic placement of bromo, chloro, and fluoro substituents allows for sequential functionalization under controlled conditions. Its bench-stable nature and compatibility with standard reaction protocols make it well-suited for the synthesis of complex heterocyclic scaffolds and API intermediates.

General Information

CAS No. 1033203-44-9
Cat. No. CS-0146033
Purity ≥95%
MDL No. MFCD11100658
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂BrClFN
Molecular Weight 210.43
Synonym(s) None
SMILES FC1=CN=C(Br)C=C1Cl

Computational Chemistry Data

TPSA 12.89
LogP 2.6366
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-4-chloro-5-fluoropyridine

CAS No. 1033203-44-9

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