2,2-Difluoro-2-(pyridin-2-yl)acetic acid

Name: 2,2-Difluoro-2-(pyridin-2-yl)acetic acid
Brand: ChemScene
Availability: InStock
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CAS No. 1039621-73-2
Cat. No. CS-0052190
Purity≥98%
MDL No.MFCD11858606

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2,2-Difluoro-2-(pyridin-2-yl)acetic acid|CS-0052190

Structure of 1039621-73-2

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Description

This pyridyl-substituted difluoroacetic acid features a sterically constrained α,α-difluoro motif paired with a heteroaromatic pyridin-2-yl group, enabling enhanced metabolic stability and improved membrane permeability. The electron-deficient acetic acid moiety integrates readily into bioactive scaffolds for medicinal chemistry applications.

Application

2,2-Difluoro-2-(pyridin-2-yl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the introduction of a strongly electron-withdrawing difluoromethyl group adjacent to a pyridine moiety. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate efficient incorporation into bioactive scaffolds. The molecule functions as a key intermediate in the synthesis of fluorinated heterocycles and pharmaceutical candidates requiring enhanced metabolic stability and membrane permeability.

General Information

CAS No. 1039621-73-2
Cat. No. CS-0052190
Purity ≥98%
MDL No. MFCD11858606
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅F₂NO₂
Molecular Weight None
Synonym(s) 2-Pyridineacetic acid, a,a-difluoro-
SMILES OC(=O)C(F)(F)C1=NC=CC=C1

Computational Chemistry Data

TPSA 50.19
LogP 1.258
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 2

Safety Information

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Precautionary Statements : N/A

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,2-Difluoro-2-(pyridin-2-yl)acetic acid

CAS No. 1039621-73-2

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