4-Amino-5-bromo-2-methylpyridine

Name: 4-Amino-5-bromo-2-methylpyridine
Brand: ChemScene
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CAS No. 10460-50-1
Cat. No. CS-W008956
Purity≥97%
MDL No.MFCD07368860

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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4-Amino-5-bromo-2-methylpyridine|CS-W008956

Structure of 10460-50-1

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Description

4-Amino-5-bromo-2-methylpyridine features a pyridine core functionalized with amino, bromo, and methyl groups at distinct positions, enabling selective coupling reactions. The electron-donating amino group enhances reactivity in cross-coupling processes, while the bromo substituent serves as a reliable handle for palladium-catalyzed transformations. This molecule combines synthetic versatility with bench-stable handling, making it well-suited for building complex heterocyclic architectures in medicinal chemistry and materials science applications.

Application

4-Amino-5-bromo-2-methylpyridine serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The amino group enables direct coupling reactions, while the bromo substituent facilitates palladium-catalyzed cross-couplings. The methyl group enhances metabolic stability and modulates electronic properties. This compound exhibits excellent bench stability and is compatible with standard purification protocols, making it ideal for iterative synthetic workflows in medicinal chemistry and process development.

General Information

CAS No. 10460-50-1
Cat. No. CS-W008956
Purity ≥97%
MDL No. MFCD07368860
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇BrN₂
Molecular Weight 187.04
Synonym(s) 5-Bromo-2-methyl-4-pyridinamine
SMILES NC1=CC(C)=NC=C1Br

Computational Chemistry Data

TPSA 38.91
LogP 1.73472
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Amino-5-bromo-2-methylpyridine

CAS No. 10460-50-1

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